Automated calculation of infarct transmurality

The aim of this study was to develop an algorithm to automatically calculate infarct transmurality based on a non dichotomous infarct classification, and to compare with manual delineation. Global transmurality as calculated by the computer algorithm were significantly smaller than the consensus delineation of three observers (p<0.05). On a regional basis in 6 sectors of each slice the variability of the three observers compared to consensus delineation was 17%, 15%, and 20%. The variability of the automated algorithm was 16%. In conclusion, weighted calculation of transmurality gave smaller global transmurality compared to consensus delineation, but did had the same variability on a regional basis.