Robust prediction of atrial fibrillation termination usingwavelet bidomain entropy analysis

The ability to predict if an AF episode terminates spontaneously or not is a challenging clinical problem. This work presents a robust AF prediction method carried out by estimating, through regularity indexes, the atrial activity (AA) organization increase prior to AF termination. This regularity variation appears as a consequence of the decrease in the number of reentries into the atrial tissue. AA was obtained from surface ECG recordings using an average QRST template cancellation technique. Wavelet transform (WT) was used in a bidomain way (time and frequency) in order to improve organization estimation. Thereafter, a more robust classification process for terminating and non-terminating AF episodes was developed making use of two different wavelet decomposition strategies. Finally, the AA organization both in time and wavelet domains was estimated. Through the application of this strategy, 96% of the terminating and non-terminating analyzed AF episodes were correctly classified.