A tissue-level electromechanical model of the left ventricle: Application to the analysis of intraventricular pressure

This paper presents a model-based method for the analysis of experimental intraventricular pressure. The proposed approach is composed of a ventricular model and an identification algorithm. A multi-formalism, tissue-level electromechanical model of the left ventricle is proposed. Parameter identification is based on evolutionary algorithms and is applied to reproduce experimental pressures obtained from three pigs in steady-state conditions, during afterload variations and during ischemia. Identification results show the capability of the model to reproduce observed intraventricular pressure morphologies and to assist in the interpretation of these signals.