Use of nucleotide genomic signals to determine distances between mitochondrial DNA genes of mammals

The nucleotide genomic signal (NuGS) methodology offers a molecular level way to compute the distance between various species or between individuals in the same species, starting from the distances between homologous genes or between conserved equivalent non-coding genome regions. The paper illustrates the use of the nucleotide imbalance signal (N) to determine the distances between mitochondrial DNA (mtDNA) genes of several mammals, including humans. The results are in accordance with those of other genetic or phylogenetic approaches to establish distances between genes, individuals, populations and species.