Applying computational fluid dynamics to a spatially correct 3D reconstruction of a coronary arterial segment in the individual patient

Presently no technique is available which provides 3D-shear stress data in human coronary arteries in vivo. Shear stress imposed by blood on the endothelium is, for instance, indicated as the most prominent hemodynamic factor to correlate with atherosclerotic plaque development. In this study we present a novel technique, which uses the recently developed 3D reconstruction technique ANGUS, to calculate with the aid of an FEM software package (SEPRAN) velocity profiles and shear stress on the endothelium. This novel technique enables to calculate at corresponding locations shear stress and wall thickness. Application of the technique in a first study in an atherosclerotic right coronary artery showed that low shear stress areas correspond to areas with maximal wall thickness. In conclusion we present a novel technique which enables to evaluate in the human individual patient local wall thickness and shear stress