Performance evaluation on effect of pre-sonication on nanoparticulates during wet nano-milling of drugs

Nano-sizing of drug particle size has been identified as a potentially effective method to increase solubility and hence drug effectiveness. By nanomilling, stable nano-scale particulates can be prepared which have improved physical properties. Nanoparticulates of poorly water-soluble drugs can be prepared by milling of drugs into nano range and achieve optimal stability condition. In this study, effect of pre-sonication followed by wet grinding was assessed on the particle sizes of griseofulvin and ketoconazole in dispersions containing surfactants. The sizes of drugs particulates were reduced to less than 200 nm in size with a polydispersity index (PDI) below than 1.0 when pre-sonication and nanomilling were applied consecutively.