Antioxidant and Cytotoxic Activity of the Ethanol Extract from Red Toon Leaves

Author

Chen, Chungang ; Liu, Benguo ; Han, Fenxia ; Zhang, Huirong

Author_Institution

Sch. of Food Sci., Henan Inst. of Sci. & Technol., Xinxiang, China

fYear

2010

fDate

23-25 April 2010

Firstpage

1

Lastpage

3

Abstract

Red toon leaves have been consumed as herbal medicine and vegetable. In this study, the antioxidant and cytotoxic activities of its ethanol extract were investigated. The results showed that the extract was an effective scavenger in quenching hydroxyl radicals with IC50 of 10.57 mg/mL. A linear correlation between concentration of the extract and reducing power was observed with a coefficient of r2 = 0.9978. And the extract could inhibit lard oil oxidation in Rancimat test with protect factor of 1.31. In the cytotoxic test, the extract could significantly inhibit the growth of human epidermal carcinoma cancer A431 and human lung cancer A549 cells with a concentration-dependent manner.

Keywords

cancer; cellular biophysics; free radicals; lung; organic compounds; oxidation; pharmaceuticals; skin; toxicology; Rancimat test; antioxidant activity; cytotoxic activity; ethanol extract; human epidermal carcinoma cancer; human lung cancer; hydroxyl radicals; lard oil oxidation; protect factor; red toon leaves; Animals; Cancer; Chemical analysis; Ethanol; Food technology; Humans; Oxidation; Petroleum; Protection; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Computer Science (ICBECS), 2010 International Conference on

Conference_Location

Wuhan

Print_ISBN

978-1-4244-5315-3

Type

conf

DOI

10.1109/ICBECS.2010.5462417

Filename

5462417