A beam-through algorithm to compute multiple sequence alignment

This paper discusses a new approach beam-through alignment (BTA) to multiple sequence alignment. With the beam sources given by using pairwise alignment, BTA detects the possible channel for specific beam source, and arrange most similar segments in common columns to form a beam for the current beam source. Then use already found beams as cut points to divide sequences to several parts for further alignment recursively. By split the least beam passed sequence step by step, BTA constructs a phylogenetic tree.