A Pore Network Model Based Method for Tissue Engineering Scaffold Design

This paper presents a Pore Network Model (PNM) based methods for design scaffold. In this modeling process, plenty of unit spheres that distributed in space coordinate randomly with different diameter within limits are created and permeated into the whole scaffold space. When the total volume proportion of the unit spheres ascends to a certain value, a PNM model is formed with the topological structure of connective holes and pore throats. The pore size, porosity and connectivity of the PNM Scaffold can be macroscopic controlled. Its irregular structure ensures the structure anisotropy on microstructure.