Bioactive surface modification for neurite development

Author

Potember, Richard S. ; Matsuzawa, Mieko ; Liesi, Päivi

Author_Institution

Appl. Phys. Lab., Johns Hopkins Univ., Laurel, MD, USA

fYear

1994

fDate

1994

Firstpage

842

Abstract

A combination of photolithographic and chemical techniques were used to prepare biologically active patterned substrates to guide the development of neurons in culture. A synthetic peptide, derived from the B2 chain of laminin was chemically attached to patterned silicon surfaces to promote the development and guidance of embryonic rat hippocampal neurons. On parallel lines, neurons developed a mature bipolar morphology. These modified surfaces may be an important element of future biosensors and neural prosthetic devices

Keywords

biological techniques; cellular biophysics; neurophysiology; photolithography; substrates; Si; bioactive surface modification; biologically active patterned substrates; biosensors; embryonic rat hippocampal neurons; laminin B2 chain; mature bipolar morphology; neural prosthetic devices; neurite development; patterned silicon surfaces; synthetic peptide; Amino acids; Chemical elements; Chemical technology; Embryo; Laboratories; Neurons; Peptides; Physics; Substrates; Surface morphology;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Conference_Location

Baltimore, MD

Print_ISBN

0-7803-2050-6

Type

conf

DOI

10.1109/IEMBS.1994.415174

Filename

415174