Nucleotide genomic signals methodology

The nucleotide genomic signals (NuGS) methodology is based on the conversion of symbolic nucleotide sequences into digital genomic signals. The representation we use is unbiased, i.e., adequate for a large spectrum of problems related to DNA analysis. The NuGS methodology can be used both for the analysis of large scale features of genomic sequences, maintained over distances of 106 - 108 base pairs, allowing to reveal hidden features and ancestral structures of nucleotide sequences, but also for the local study of nucleotide sequences, such as in the analysis of pathogen variability, important in the context of the development of pathogen resistance to treatment.