2D-5 Ultrasonic Characterization of Novel Monodispersed Contrast Agents

Author

Shi, William ; Bohmer, Marcel ; De Winter, Suzanne ; Steenbakkers, Jan ; Emmer, Marcia ; Van Wamel, Annemieke ; De Jong, Nico ; Hall, Christopher S.

Author_Institution

Philips Res. North America

fYear

2006

fDate

2-6 Oct. 2006

Firstpage

301

Lastpage

304

Abstract

Localized drug delivery should significantly improve the therapeutic efficacy for treatment of pathological lesions and concurrently reduce toxic exposure to the surrounding healthy tissue. A novel contrast agent, consisting of mono-dispersed gas-filled microcapsules, offers great potential for localized drug release. The destruction threshold and rate of various microcapsules and their dependence on the microcapsule size and shell thickness have been investigated via optical and acoustical measurements. The results presented in this paper will increase understanding of specific physical attributes needed to improve ultrasonically-activated drug delivery particles

Keywords

biomedical ultrasonics; drug delivery systems; ultrasonic imaging; contrast agents; drug delivery; microcapsules; ultrasonics; Acoustic measurements; Acoustic transducers; Biomedical optical imaging; Cameras; Drug delivery; High speed optical techniques; Optical scattering; Polymers; Size measurement; Ultrasonic variables measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2006. IEEE

Conference_Location

Vancouver, BC

ISSN

1051-0117

Print_ISBN

1-4244-0201-8

Electronic_ISBN

1051-0117

Type

conf

DOI

10.1109/ULTSYM.2006.88

Filename

4151944