DocumentCode :
2348592
Title :
2D-6 In Vivo Characterisation of Microbubbles using High Frequency Ultrasound
Author :
Stapleton, Shawn A P ; Goodman, Heather ; Zhou, Yu-Qing ; Cherin, Emmanuel ; Burns, Peter N. ; Foster, F. Stuart
Author_Institution :
Dept. of Med. Biophys., Toronto Univ., Ont.
fYear :
2006
fDate :
2-6 Oct. 2006
Firstpage :
305
Lastpage :
308
Abstract :
The goal of this project was to determine the utility of microbubble contrast agents in relation to mouse imaging with high frequency ultrasound. The ability to perform quantitative haemodynamic measurements using high frequency ultrasound and microbubbles is dependent on the behaviour of the contrast agent in vivo. The objective of this study was to investigate the acoustic response and kinetic behaviour of the clinical contrast agent Definitytrade in mice exposed to 30 MHz ultrasound. In vitro experiments showed that the agent behaved predominantly as linear scatterers for pressures < 300 kPa and the signal loss after 600 pulses was minimal (< 1 dB). In vivo experiments showed that the peak enhancement and duration of enhancement of the agent increased linearly for doses between 5 and 50 muL/kg. There was up to 9 times increase in peak enhancement above baseline and up to 5 minute duration of enhancement for doses > 50 muL/kg. It is believed that the utility of microbubble contrast agents for quantitative flow imaging in the mouse using high frequency ultrasound is in 5 to 50 muL/kg dose range. To summarize, the characteristics of Definitytrade injected in a mouse and exposed to 30 MHz ultrasound have been investigated
Keywords :
biomedical ultrasonics; blood flow measurement; bubbles; ultrasonic imaging; 30 MHz; Definity; haemodynamic measurements; high frequency ultrasound; microbubble contrast agents; mouse imaging; quantitative flow imaging; Acoustic imaging; Acoustic measurements; Blood flow; Frequency measurement; In vivo; Kinetic theory; Mice; Performance evaluation; Ultrasonic imaging; Ultrasonic variables measurement;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium, 2006. IEEE
Conference_Location :
Vancouver, BC
ISSN :
1051-0117
Print_ISBN :
1-4244-0201-8
Electronic_ISBN :
1051-0117
Type :
conf
DOI :
10.1109/ULTSYM.2006.89
Filename :
4151945
Link To Document :
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