Title :
1K-4 Differentiation of Dystrophic and Normal Skeletal Muscle Tissues with Energy and Entropy Images Acquired In Vivo from the Biceps of mdx and Wild-Type Mice
Author :
Wallace, Kirk D. ; Marsh, Jon N. ; Baldwin, Steven L. ; Connolly, Anne M. ; Keeling, Richard ; Lanza, Gregory M. ; Wickline, Samuel A. ; Hughes, Michael S.
Author_Institution :
Sch. of Medicine, Washington Univ., St. Louis, MO
Abstract :
Duchenne muscular dystrophy is a severe wasting disease, involving replacement of necrotic muscle tissue by fibrous material and fatty infiltrates. One primary animal model is the X chromosome-linked mdx strain of mice, which exhibit a clinical phenotype comparable to a mild expression of Duchenne muscular dystrophy in humans. The goals of the present work were to validate and quantify the capability of both energy and entropy metrics of radio-frequency ultrasonic backscatter to differentiate among normal, dystrophic, and steroid treated skeletal muscle in the mdx model
Keywords :
biomedical ultrasonics; diseases; muscle; Duchenne muscular dystrophy; X chromosome-linked mdx mice strain; biceps; dystrophic skeletal muscle tissues; energy images; entropy images; radio-frequency ultrasonic backscatter; wild-type mice; Animals; Biological cells; Biological materials; Capacitive sensors; Diseases; Entropy; Humans; In vivo; Mice; Muscles;
Conference_Titel :
Ultrasonics Symposium, 2006. IEEE
Conference_Location :
Vancouver, BC
Print_ISBN :
1-4244-0201-8
Electronic_ISBN :
1051-0117
DOI :
10.1109/ULTSYM.2006.280