Title :
Evaluation of in vitro drug release and in vivo tolerance of porous biodegradable reservoir device
Author :
Yang, Dachuan ; Peyman, Gholam A. ; Fillacier, Kathleen ; Khoobehi, Bahram
Author_Institution :
LSU Eye Center, Louisiana State Univ. Med. Center, New Orleans, LA, USA
Abstract :
The biodegradable polymer polycaprolactone was tested in vitro and in vivo as an intraocular drug delivery device loaded with 5-carboxyfluorescein dye. Zero-order release of carboxyfluorescein was obtained in vitro. The device was tolerated well after implantation in the rabbit eye. Further studies are necessary to determine the efficacy of this form of drug delivery
Keywords :
biomedical equipment; eye; patient treatment; polymers; 5-carboxyfluorescein dye; biodegradable polymer; in vitro drug release; in vivo tolerance; intraocular drug delivery device; polycaprolactone; porous biodegradable reservoir device; rabbit eye implantation; Biodegradable materials; Biodegradation; Diseases; Drug delivery; In vitro; In vivo; Pharmaceuticals; Polymers; Rabbits; Reservoirs;
Conference_Titel :
Biomedical Engineering Conference, 1995., Proceedings of the 1995 Fourteenth Southern
Conference_Location :
Shreveport, LA
Print_ISBN :
0-7803-2083-2
DOI :
10.1109/SBEC.1995.514418
