Title :
Development of a composite of hydroxylapatite and chitosan as a bone graft substitute
Author :
Menon, P.R. ; Mukherjee, Dipti Prasad
Author_Institution :
Louisiana Tech. Univ., Ruston, LA
Abstract :
Composites of water soluble chitosan and hydroxylspatite (HA) in the paste form were studied for the use as a synthetic bone graft material. HA powder was added to 5% aqueous solution of chitosan in different HA to chitosan ratios. Different techniques were developed to measure the viscosity, setting time, compressive moduli, and push out resistance through cadaver bone holes of the HA-chitosan pastes. An optimum formulation was selected based on the results of these measurements. A system was developed to deliver the pastes to the focal defects in the bone by modifying an arthroscopic syringe
Keywords :
bone; composite materials; compressibility; prosthetics; stress-strain relations; viscosity; HA; HA-chitosan pastes; arthroscopic syringe; bone graft substitute; cadaver bone holes; composite; compressive moduli; focal defects; hydroxylapatite; paste form; push out resistance; setting time; synthetic bone graft material; viscosity; water soluble chitosan; Analysis of variance; Bones; Cadaver; Electrical resistance measurement; Immune system; Orthopedic surgery; Powders; Testing; Time measurement; Viscosity;
Conference_Titel :
Biomedical Engineering Conference, 1995., Proceedings of the 1995 Fourteenth Southern
Conference_Location :
Shreveport, LA
Print_ISBN :
0-7803-2083-2
DOI :
10.1109/SBEC.1995.514446
