Title :
The effect of surface properties of gold nanoparticles on cellular uptake
Author :
Yang, Jing ; Zeng, Jie ; Kong, Tao ; Wang, Xiaoping ; Roa, Wilson ; El-Bialy, T. ; Xing, James ; Chen, Jie
Author_Institution :
Alberta Univ., Edmonton
Abstract :
In this study, we developed GNPs with various types of chemical surface features and evaluated how these features led nanoparticles to selectively bind to different target cell sites. Results showed that selective binding was successful in producing high concentrations in target locations. We also explored the potential application of these GNPs to enhance the cancer cell cytotoxicity induced by radiotherapy.
Keywords :
biomedical materials; cancer; cellular biophysics; gold; nanobiotechnology; nanoparticles; radiation therapy; Au; cancer cell cytotoxicity; cellular uptake; chemical surface features; nanoparticles; radiotherapy; Conferences; Gold; Nanoparticles;
Conference_Titel :
Life Science Systems and Applications Workshop, 2007. LISA 2007. IEEE/NIH
Conference_Location :
Bethesda, MD
Print_ISBN :
978-1-4244-1813-8
Electronic_ISBN :
978-1-4244-1813-8
DOI :
10.1109/LSSA.2007.4400892
