DocumentCode
2355961
Title
Adaptation of a minimal four-state cell model for reproducing atrial excitation properties
Author
Weber, FM ; Lurz, S. ; Keller, DUJ ; Weiss, DL ; Seemann, G. ; Lorenz, C. ; Dössel, O.
Author_Institution
Univ. Karlsruhe (TH), Karlsruhe
fYear
2008
fDate
14-17 Sept. 2008
Firstpage
61
Lastpage
64
Abstract
Simulation of cardiac excitation is often a trade-off between accuracy and speed. A promising minimal, time-efficient cell model with four state variables has recently been presented together with parametrizations for ventricular cell behaviour. In this work, we adapt the model parameters to reproduce atrial excitation properties as given by the Courtemanche model. The action potential shape is considered as well as the restitution of action potential duration and conduction velocity. Simulation times in a single cell and a tissue patch are compared between the two models. We further present the simulation of a sinus beat on the atria in a realistic 3D geometry using the fitted minimal model in a monodomain simulation.
Keywords
biological tissues; cardiology; cellular biophysics; Courtemanche model; atria; atrial excitation; conduction velocity; minimal four-state cell model; realistic 3D geometry; sinus beat; tissue patch; Automata; Current density; Equations; Europe; Frequency; Geometry; Mathematical model; Shape control; Solid modeling; Voltage;
fLanguage
English
Publisher
ieee
Conference_Titel
Computers in Cardiology, 2008
Conference_Location
Bologna
ISSN
0276-6547
Print_ISBN
978-1-4244-3706-1
Type
conf
DOI
10.1109/CIC.2008.4748977
Filename
4748977
Link To Document