• DocumentCode
    2355961
  • Title

    Adaptation of a minimal four-state cell model for reproducing atrial excitation properties

  • Author

    Weber, FM ; Lurz, S. ; Keller, DUJ ; Weiss, DL ; Seemann, G. ; Lorenz, C. ; Dössel, O.

  • Author_Institution
    Univ. Karlsruhe (TH), Karlsruhe
  • fYear
    2008
  • fDate
    14-17 Sept. 2008
  • Firstpage
    61
  • Lastpage
    64
  • Abstract
    Simulation of cardiac excitation is often a trade-off between accuracy and speed. A promising minimal, time-efficient cell model with four state variables has recently been presented together with parametrizations for ventricular cell behaviour. In this work, we adapt the model parameters to reproduce atrial excitation properties as given by the Courtemanche model. The action potential shape is considered as well as the restitution of action potential duration and conduction velocity. Simulation times in a single cell and a tissue patch are compared between the two models. We further present the simulation of a sinus beat on the atria in a realistic 3D geometry using the fitted minimal model in a monodomain simulation.
  • Keywords
    biological tissues; cardiology; cellular biophysics; Courtemanche model; atria; atrial excitation; conduction velocity; minimal four-state cell model; realistic 3D geometry; sinus beat; tissue patch; Automata; Current density; Equations; Europe; Frequency; Geometry; Mathematical model; Shape control; Solid modeling; Voltage;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Computers in Cardiology, 2008
  • Conference_Location
    Bologna
  • ISSN
    0276-6547
  • Print_ISBN
    978-1-4244-3706-1
  • Type

    conf

  • DOI
    10.1109/CIC.2008.4748977
  • Filename
    4748977