Electrophysiologically detailed models of the right and left rabbit atria: Pharmacological impacts on propagation and arrhythmogenesis

Experimentally observed differences in the action potential (AP) properties - primarily, refractoriness - between the left (LA) and right (RA) atria are believed to be important in maintaining atrial fibrillation (AF). However, relationships between the underlying ionic differences in the LA and RA cells, as well as their impacts on the tissue refractoriness and susceptibility to AF are unknown. We quantify such relationships by developing detailed AP models for LA and RA, studying refractory and vulnerable properties of both tissues, and pharmacological impacts controlling them.