DocumentCode :
2356840
Title :
P3E-3 Finite Element Modeling of Ultrasound Scattering by Spherical Objects and Cells
Author :
Falou, O. ; Kumaradas, J.C. ; Kolios, M.C.
Author_Institution :
Dept. of Electr. & Comput. Eng., Ryerson Univ., Toronto, Ont.
fYear :
2006
fDate :
2-6 Oct. 2006
Firstpage :
2072
Lastpage :
2075
Abstract :
It has been shown that high-frequency ultrasound (20 MHz-60 MHz) can be used to detect structural and physical changes in tissues and cell ensembles during cell death. However, the changes observed are not well understood. Recent theoretical models treating the cell as a homogeneous sphere did not show good agreement with experimental data. We have recently developed a finite element model of wave propagation through inhomogeneous spherical structures (COMSOL Multiphysics, COMSOL Inc., Burlington, MA) to solve the problem of high-frequency acoustic scattering from cells. We will discuss the improvement to our previous model by using a second-order boundary condition. The improved model predicts scattering by a homogeneous sphere with a 2% average accuracy when compared to the Faran model. Applications of the model to ultrasound scattering by two types of objects that represent biological cells will be presented. In both applications the cell is a sphere (representing the nucleus) surrounded by a spherical shell (representing the cytoplasm). The cytoplasm has either an elastic property with a stiffness less than that of the nucleus, or is fluid, having similar physical properties to water. The deformations of an air-filled microbubble subject to various acoustic wave frequencies will also be presented. Finally, the significance of this work on the prediction of ultrasound backscatter from cells, and on ultrasound tissue characterization techniques will be discussed
Keywords :
acoustic wave scattering; biomedical ultrasonics; cellular biophysics; finite element analysis; 20 to 60 MHz; COMSOL Multiphysics; Faran model; biological cells; cell nucleus; cytoplasm; elastic property; finite element modeling; inhomogeneous spherical structures; second-order boundary condition; stiffness; ultrasound scattering; ultrasound tissue characterization techniques; Acoustic propagation; Acoustic scattering; Acoustic waves; Biological cells; Biological system modeling; Boundary conditions; Finite element methods; Predictive models; Ultrasonic imaging; Water;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium, 2006. IEEE
Conference_Location :
Vancouver, BC
ISSN :
1051-0117
Print_ISBN :
1-4244-0201-8
Electronic_ISBN :
1051-0117
Type :
conf
DOI :
10.1109/ULTSYM.2006.525
Filename :
4152381
Link To Document :
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