Title :
Feedback control of resonant drift as a tool for low voltage defibrillation
Author :
Biktasheva, Irina V. ; Morgan, Sw ; Plank, G. ; Biktashev, VN
Author_Institution :
Univ. of Liverpool, Liverpool
Abstract :
Resonant drift of re-entry occurs in response to repetitive stimulation with period equal to that of the re-entry. Feedback controlled resonant drift drives re-entry out from excitable tissue, so may be used as antiarrthymic or defibrillation strategy. To test it in realistic computer simulations, we used monodomain and bidomain description of the tissue, rectangular 2D and 3D geometry, and anatomically realistic rabbit ventricles geometry, with Barkley, Drouhard-Roberge-Beeler-Reuter, and Courtemanche-Ramirez-Nattel kinetics models. Re-entries terminated at a fraction of the conventional shock strength. The success depends on the details of the feedback protocol. The simulations motivate experimental testing of the proposed low-voltage defibrillation method, which will be most productive in conjunction with simulations.
Keywords :
biological tissues; cardiology; defibrillators; feedback; medical control systems; patient treatment; Barkley kinetics model; Courtemanche-Ramirez-Nattel kinetics model; Drouhard-Roberge-Beeler-Reuter kinetics model; antiarrthymic strategy; computer simulations; feedback controlled resonant drift; feedback protocol; low-voltage defibrillation; rabbit ventricles geometry; rectangular 2D geometry; rectangular 3D geometry; tissue bidomain description; tissue monodomain description; Adaptive control; Computational geometry; Computer simulation; Defibrillation; Feedback control; Kinetic theory; Low voltage; Rabbits; Resonance; Testing;
Conference_Titel :
Computers in Cardiology, 2008
Conference_Location :
Bologna
Print_ISBN :
978-1-4244-3706-1
DOI :
10.1109/CIC.2008.4749088