Circuit model of neuronal spatial-temporal processing

Author

Levine, Michael D.

Author_Institution

Naval Res. Lab., Washington, DC, USA

fYear

1994

fDate

1994

Firstpage

734

Abstract

A circuit model for the membrane of the input region of a neuron is developed for SPICE simulation. The model incorporates multiple synaptic inputs, which arise from the spatial distribution of transmitter-gated ion channels in the postsynaptic membrane. The activation of groups of ion channels is simulated in a temporally distributed sequence. The circuit provides a plausible representation of spatial and temporal processing in an individual neuron and thereby can serve as a model for developing a sophisticated processing element in a biological neural network

Keywords

SPICE; bioelectric phenomena; biomembrane transport; cellular biophysics; neurophysiology; physiological models; SPICE simulation; biological neural network; circuit model; ion channels groups activation; neuron input region; neuronal spatial-temporal processing; postsynaptic membrane; sophisticated processing element; temporally distributed sequence; transmitter-gated ion channels spatial distribution; Biological system modeling; Biomembranes; Capacitance; Circuit simulation; FETs; MOSFET circuits; Neurons; Neurotransmitters; SPICE; Threshold voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Conference_Location

Baltimore, MD

Print_ISBN

0-7803-2050-6

Type

conf

DOI

10.1109/IEMBS.1994.415266

Filename

415266