Cardiac arrhythmias induced by an electrical stimulation at a cellular level

Author

Jacquir, S. ; Binczak, S. ; Vandroux, D. ; Laurent, G. ; Athias, P. ; Bilbault, Jm

Author_Institution

Lab. LE2I UMR CNRS 5158, Univ. of Burgundy, Dijon

fYear

2008

fDate

14-17 Sept. 2008

Firstpage

625

Lastpage

628

Abstract

To provide insights into the impulse propagation between cardiac myocytes, we performed studies of excitation spread with cellular resolution in confluent monolayers of cultured cardiomyocytes (CM). Multisite field potentials have been recorded using microelectrode arrays (MEA) technology in a basal condition and in proarrhythmic conditions induced by a high frequency electrical stimulation. The in vitro observation of spiral waves opens a new way to test the anti-arrhythmic drugs or strategies at cellular level.

Keywords

bioelectric phenomena; biomedical electrodes; cardiology; cellular transport; basal condition; cardiac myocyte impulse propagation; cardiomyocyte confluent monolayers; cellular level electrical stimulation; electrical stimulation induced cardiac arrhythmia; excitation spread; high frequency electrical stimulation; microelectrode arrays; multisite field potentials; proarrhythmic conditions; spiral waves; Biological materials; Cardiology; Electrical stimulation; Fibrillation; Frequency; Hospitals; Microelectrodes; Pediatrics; Rhythm; Spirals;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology, 2008

Conference_Location

Bologna

ISSN

0276-6547

Print_ISBN

978-1-4244-3706-1

Type

conf

DOI

10.1109/CIC.2008.4749119

Filename

4749119