Development of fabrication and detection system for centrifugal force and thermal management biochip

The development of micro-electro-mechanical systems (MEMS) advances the success of microfabricated devices, and microfabricated devices offer many specific platforms that can integrate a laboratory on a chip and manage micro biochemical reaction analysis. Nevertheless, most microfabricated devices, especially in biochip design, depend on semi-conductor or LIGA process so that the configuration of devices is complex and money-consumed. Furthermore, miniaturization in nano-scale isn\´t always significant in bio-medical reactions. Thus, the aim of our research is to develop a fabrication and detection system of centrifugal-force and thermal management biochip, which improves the complex pumps and valves designed by semi-conductor application in lab-on-a-chip, and it saves time and money in the comparison of traditional lab technology. Our system uses the soft-ware-SolidWorks and computer numerical control (CNC) machine to design microfluidic patterns, the heat pressure machine with feedback control of temperature sensor to design the hermetically sealed biochip, and the centrifugal machine with server frequency conversion motor to lead sample mobility by centrifugal force instead of pumps and valves. The hardware of this system includes three parts: centrifugal machine, heat pressure machine, and microfluidic fabrication; the application of the biochip is to detect clinical and medicine bio-reactions. Our "fabrication and detection system for centrifugal-force and thermal management biochip" developed in this study is a on-table facility and can use in several areas of medical and clinical examinations, it can also combine with polymerase chain reaction (PCR) by adding temperature controlling procedure in the future.