Analysis of the noise associated to the muscarinic modulation of the mouse perirhinal cortex

The perirhinal cortex (PRC) is a polymodal associative area which plays a key role in several memory processes. It has been shown that cholinergic muscarinic modulation plays a crucial role in regulating PRC functions. In this work, changes in the signal noise during muscarinic modulation of the PRC have been observed and analyzed. The relationship between these changes and the information processing performed by neurons of the PRC are inevstigated. In more details, the effects of muscarinic modulation on the membrane potential and on the voltage membrane noise of pyramidal neurons and GABAergic interneurons are inevstigated, both from deep and superficial layers of the PRC.