Analysis of regional left ventricular function in the post-infarct mouse by magnetic resonance imaging with retrospective gating

Author

Caiani, E.G. ; Franzosi, M. ; Castiglioni, L. ; Guerrini, U.

Author_Institution

Biomed. Eng. Dpt, Politec. di Milano, Milan

fYear

2008

fDate

14-17 Sept. 2008

Firstpage

1101

Lastpage

1104

Abstract

Our aim was to test, in a murine myocardial infarction (MMI) model, the feasibility of a new MRI protocol with no ECG/respiratory gating, and compare normal mice versus MMI, in terms of global and regional LV function. A control group (C, 10 mice) and a MMI group (18 mice) were studied. MRI with retrospective gating was performed. End-diastolic (EDV) and end-systolic (ESV) LV volumes with ejection fraction (EF) were computed. In addition, regional fractional area change (RFAC) was used as index of regional wall motion. In MMI, LV size (in muL) was larger compared to C (EDV: 92plusmn25 vs 36plusmn4, ESV: 66plusmn27 vs 10plusmn3), with a significant decrease in EF (31plusmn10 vs 72plusmn7%). RFAC in C showed heterogeneous values. In MMI, RFAC decreased from LV base to apex, with a min (26%) in the anterior segment, in agreement with the occluded LAD. MRI with retrospective gating is feasible in mice, and regional LV function analysis allows the localization of the induced infarction.

Keywords

biomedical MRI; cardiovascular system; diseases; image reconstruction; image sampling; medical image processing; muscle; EDV; ESV; MMI; RFAC; ejection fraction; end-diastolic LV volume; end-systolic LV volume; heterogeneous value; image reconstruction; image sampling; magnetic resonance imaging; murine myocardial infarction model; regional fractional area change; regional left ventricular function analysis; regional wall motion; retrospective gating; Animals; Image analysis; Image resolution; Magnetic analysis; Magnetic resonance imaging; Mice; Myocardium; Protocols; Spatial resolution; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology, 2008

Conference_Location

Bologna

ISSN

0276-6547

Print_ISBN

978-1-4244-3706-1

Type

conf

DOI

10.1109/CIC.2008.4749238

Filename

4749238