DocumentCode :
2363366
Title :
Spatially adaptive subject level analyses improve random effects fMRI group studies
Author :
Badillo, Solveig ; Vincent, Thomas ; Ciuciu, Philippe
Author_Institution :
Neurospin, CEA, Gif-sur-Yvette, France
fYear :
2010
fDate :
7-10 Nov. 2010
Firstpage :
1
Lastpage :
5
Abstract :
Inter-subject analysis of functional Magnetic Resonance Imaging (fMRI) data relies on single intra-subject studies, which are usually conducted using a massively univariate approach. In this paper, we investigate the impact of an improved intra-subject analysis on group studies. Our approach is based on the use of Adaptive Spatial Mixture Models within a joint detection-estimation (JDE) framework [1]. In this setting, spatial variability is achieved at a regional scale by the explicit characterization of the hemodynamic filter and at the voxel scale by an adaptive spatial correlation model between condition-specific effects. For the group statistics, we conducted several Random effect analyses (RFX) which relied either on SPM or JDE intra-subject analyses. We performed a comparative study on two different real datasets involving the same paradigm and the same 15 subjects but eliciting different noise levels by varying the acceleration factor (R=2 and R=4) in parallel MRI acquisition. We show that brain activations appear more spatially resolved using JDE instead of SPM and that a better sensitivity is achieved. Moreover, the JDE framework provides more robust detection performance by maintaining satisfying results on our most noisy real dataset.
Keywords :
adaptive signal processing; biomedical MRI; data acquisition; medical image processing; neurophysiology; acceleration factor; adaptive spatial mixture models; brain activations; fMRI; functional magnetic resonance imaging; hemodynamic filter; intersubject analysis; joint detection-estimation; parallel MRI acquisition; spatially adaptive subject level analysis; tandom effect analysis;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Applied Sciences in Biomedical and Communication Technologies (ISABEL), 2010 3rd International Symposium on
Conference_Location :
Rome
Print_ISBN :
978-1-4244-8131-6
Type :
conf
DOI :
10.1109/ISABEL.2010.5702904
Filename :
5702904
Link To Document :
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