Control of sarcomerogenesis-growth of the heart

Author

Drzewiecki, Gary M. ; Karam, E.H.

Author_Institution

Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA

fYear

1989

fDate

27-28 Mar 1989

Firstpage

9

Lastpage

10

Abstract

A theory for the growth of the cardiac sarcomere and heart size is proposed. The stress-strain environment and O₂ consumption are computed for the myocardium using a mechanical model of the left ventricle. Cardiac afterload and preload are maintained constant while the dimensions of the ventricle are altered. It is observed that the computed ventricular dimensions result in normal heart function, based on examination of stroke volume, heart rate, and ventricular pressure. Global quantities were not necessarily optimal. It is theorized that sarcomerogenesis is stimulated by an increase in the fiber stress along the myofibril

Keywords

biocontrol; biomechanics; cardiology; physiological models; O₂; O₂ consumption; cardiac afterload; cardiac preload; cardiac sarcomere; computed ventricular dimensions; fiber stress; heart growth; heart rate; heart size; left ventricle; mechanical model; myocardium; myofibril; normal heart function; sarcomerogenesis control; stress-strain environment; stroke volume; ventricular pressure; Arteries; Biomedical engineering; Heart rate; Hemodynamics; Laboratories; Myocardium; Optical fiber theory; Optimal matching; Shape; Stress;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1989., Proceedings of the 1989 Fifteenth Annual Northeast

Conference_Location

Boston, MA

Type

conf

DOI

10.1109/NEBC.1989.36672

Filename

36672