Measuring pairwise distances among sequences of the miR-15/107 group of miRNA gene

Author

Tee, Sim-Hui

Author_Institution

Multimedia Univ., Cyberjaya, Malaysia

fYear

2011

fDate

20-23 March 2011

Firstpage

703

Lastpage

706

Abstract

The miR-15/107 group of miRNA gene has been recognized as an important regulatory mechanism for main biochemical pathways in human. It has significant role to play in regulating gene expression that relevant to cardiovascular diseases, cancers and neurodegenerative diseases. Notwithstanding the fact that miRNA has strong implication on human health, an exhaustive taxonomic classification for the miR-15/107 group is impossible because the phylogeny of this group is incomplete. This paper aims at measuring pairwise distances among sequences of the miR-15/107 group of miRNA gene. The distance function allows bioinformaticians to compare the sequence of miR-15/107 group of miRNA gene and predict its target sites.

Keywords

cancer; cardiovascular system; cellular biophysics; genetics; neurophysiology; biochemical pathway; cancer; cardiovascular disease; gene expression; miR-15/107 group; miRNA gene; neurodegenerative disease; pairwise distance; phylogeny; taxonomic classification; Algorithm design and analysis; Bioinformatics; Genomics; Hidden Markov models; Humans; RNA;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers & Informatics (ISCI), 2011 IEEE Symposium on

Conference_Location

Kuala Lumpur

Print_ISBN

978-1-61284-689-7

Type

conf

DOI

10.1109/ISCI.2011.5959002

Filename

5959002