Action potential propagation in ischemic cardiac tissue: a theoretical computer modeling

Author

Cimponeriu, A. ; Starmer, Cf ; Bezerianos, A.

Author_Institution

Dept. of Med. Phys., Patras Univ., Greece

fYear

1998

fDate

13-16 Sep 1998

Firstpage

317

Lastpage

320

Abstract

In order to identify generic mechanisms for altering the ECG during ischemia, we explored changes in the action potential propagation during different ischemic conditions using simple cellular models. Based on the Beeler-Reuter and Lou-Rudy I cellular models, we developed a ventricular tissue model for probing how alterations in shape and propagation of action potential distorted the theoretical ECG signal. If arrhythmias are a characteristic of acute ischemia, the changes in ST segment duration and T wave shape seems to be related with chronic ischemia and presence of the unexcitable medium. During different stages of ischemia, the changes in theoretical ECG indicated possibilities for detecting the relation between cellular changes and external measurement of the electrical activity of the heart

Keywords

bioelectric potentials; biomembrane transport; diseases; electrocardiography; medical signal processing; muscle; physiological models; signal reconstruction; Beeler-Reuter model; ECG alteration; ECG signal reconstruction; Lou-Rudy I model; ST segment duration; T wave shape; action potential propagation; acute ischemia; arrhythmias; computer modeling; generic mechanisms; ion channels; ischemic cardiac tissue; myocardium; simple cellular models; ventricular tissue model; Biomembranes; Cardiac tissue; Cardiology; Cells (biology); Electrocardiography; Extracellular; Heart; Ischemic pain; Myocardium; Shape;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1998

Conference_Location

Cleveland, OH

ISSN

0276-6547

Print_ISBN

0-7803-5200-9

Type

conf

DOI

10.1109/CIC.1998.731797

Filename

731797