Title :
An autoregulated pulsed-DC mode iontophoretic transdermal system
Author :
Carley, C. ; Wolpert, S. ; Li, J.K.-J.
Author_Institution :
Cardiovascular Res. Lab., Rutgers Univ., Piscataway, NJ, USA
Abstract :
An autoregulated pulsed-DC iontophoretic device with slow turn-on current has been developed. A specialized high-frequency pulse with a duty cycle of 50% or less is used which will reduce skin irritation due to polarization effects. To avoid patient discomfort, current delivery is increased gradually over a two-minute period to allow the skin to adapt to the applied current level. The rate of drug delivery is regulated by controlling the energy of the delivered pulse. For antihypertensive-drug administration, the device measures the arterial pressure and continually readjusts delivery rates to keep it close to a desired target value
Keywords :
bioelectric phenomena; electrophoresis; patient treatment; skin; antihypertensive-drug administration; arterial pressure; autoregulated pulsed-DC mode iontophoretic transdermal system; drug delivery rate; polarization effects; skin irritation effects; Cardiology; Circuit synthesis; Drug delivery; Electrodes; Frequency; Patient monitoring; Polarization; Pulse generation; Skin; Space vector pulse width modulation;
Conference_Titel :
Bioengineering Conference, 1989., Proceedings of the 1989 Fifteenth Annual Northeast
Conference_Location :
Boston, MA
DOI :
10.1109/NEBC.1989.36693
