A light-scattering technique for investigating the destruction of ultrasound contrast agents

Author

Chen, Wen-Shiang ; Matula, Thomas J. ; Crum, Lawrence A.

Author_Institution

Appl. Phys. Lab., Washington Univ., Seattle, WA, USA

Volume

2

fYear

2001

fDate

2001

Firstpage

1683

Abstract

A technique that utilizes light-scattering from a low-powered laser to probe ultrasound contrast agents is described. A He-Ne laser illuminates the focal zone of a high-intensity focused ultrasound (HIFU) source operating at 1.1 MHz. A focusing lens is used to collect the scattered light from bubbles in the focal region, focusing the scattered light onto a photodetector. During application of the HIFU source, the bubbles oscillate, and the resulting fluctuation in the light-scattering signal is detected by the photodetector. Measurements of the light fluctuation can be correlated with bubble activity, especially inertial cavitation. A description of the technique, and preliminary results of measurements with ultrasound contrast agents are shown

Keywords

biomedical ultrasonics; bubbles; cavitation; light scattering; measurement by laser beam; ultrasonic imaging; 1.1 MHz; He-Ne; He-Ne laser illumination; US contrast agents destruction; bubble activity; bubble oscillation; contrast agent microbubbles; focal region; focusing lens; high-intensity focused US source; inertial cavitation; light fluctuation; light-scattering technique; low-powered laser probe; photodetector; ultrasound contrast agents; Acoustic scattering; Acoustic transducers; Biomedical measurements; Focusing; Light scattering; Mie scattering; Optical scattering; Ultrasonic imaging; Ultrasonic transducers; Ultrasonic variables measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2001 IEEE

Conference_Location

Atlanta, GA

Print_ISBN

0-7803-7177-1

Type

conf

DOI

10.1109/ULTSYM.2001.992045

Filename

992045