Title :
Submicron contrast agents for the detection and localization of at risk lymph nodes
Author :
Patel, Divia ; Dayton, Paul ; Gut, Jana ; Wisner, Erik ; Ferrara, Kathy
Author_Institution :
Dept. of Biomed. Eng., California Univ., Davis, CA, USA
Abstract :
Ultrasound contrast agents can be readily administered to facilitate detection and localization of lymph nodes at risk for regional metastasis. The agent under observation is a sub-micron, gas-filled, double-walled microsphere that ruptures when exposed to ultrasound energy at megaHertz frequencies. Optically, we observe expansion of these microbubbles over an order of magnitude in radius. These results are supported with simulations from a modified Rayleigh-Plesset model
Keywords :
biomedical ultrasonics; bubbles; cancer; US contrast agents; acoustic pressure; at risk lymph nodes detection; at risk lymph nodes localisation; center frequency; double-walled microsphere; gas-filled microsphere; microbubble disruption; microbubble expansion; modified Rayleigh-Plesset model; pulse length; regional metastasis; sentinel nodes; submicron contrast agents; ultrasound contrast agents; Acoustic pulses; Acoustic transducers; Biomedical optical imaging; Biomedical transducers; Breast cancer; Frequency; High speed optical techniques; Lymph nodes; Metastasis; Ultrasonic imaging;
Conference_Titel :
Ultrasonics Symposium, 2001 IEEE
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-7177-1
DOI :
10.1109/ULTSYM.2001.992052
