DocumentCode :
2371224
Title :
Vigilence state modulation of paired-pulse response in the rat hippocampus
Author :
Beiswanger, C. ; Austin, K. ; Bronzino, J. ; Morgane, P.J.
Author_Institution :
Worcester Found. for Exp. Biol., Shrewsbury, MA, USA
fYear :
1989
fDate :
27-28 Mar 1989
Firstpage :
103
Abstract :
The paired-pulse technique was used to establish an index of inhibition/facilitation in the dentate gyrus (DG) by determining the ratio of inhibitory to facilitatory responses to perforant path stimulation in four behavioral states (immobile waking (IW), active waking (AW), slow wave sleep (SWS), and REM sleep). In normal rats (born and reared on a 25% protein diet) at 90-120 days of age, a stimulus-response curve was determined in each behavioral state before paired-pulse testing was done at interpulse intervals (IPIs) between 20 and 1000 ms. Paired-pulse tests provide evidence of a changing ratio of inhibition to facilitation of the population spike in the DG at several IPIs. The ratio of facilitatory to inhibitory responses at short IPIs is significantly greater during AS than during IW, SWS, and REM, suggesting that inhibition (recurrent or feed-forward) may be suppressed during AW. Since prenatal nutritional insults to the developing central nervous system have effects persisting into adulthood, especially in highly plastic structures such as the hippocampus, the paired-pulse procedure was used to assess the effects of prenatal protein malnutrition on the vigilance state modulation of this inhibition/facilitation index. The major finding is that prenatal protein malnutrition results in loss of the dependence of population spike amplitude on vigilance state
Keywords :
brain; neurophysiology; 20 to 1000 ms; REM sleep; active waking; dentate gyrus; immobile waking; inhibition/facilitation; interpulse intervals; paired-pulse response; population spike; prenatal nutritional insults; protein malnutrition; rat hippocampus; ratio; responses to perforant path stimulation; slow wave sleep; stimulus-response curve; vigilance state modulation; Animals; Biology computing; Educational institutions; Feedforward systems; Hippocampus; Plastics; Protein engineering; Rats; Sleep; System testing;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioengineering Conference, 1989., Proceedings of the 1989 Fifteenth Annual Northeast
Conference_Location :
Boston, MA
Type :
conf
DOI :
10.1109/NEBC.1989.36721
Filename :
36721
Link To Document :
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