Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles

In this paper, we present a ultra high sensitive (Zeptomole, 10^-21) technique to enable the detection of any potential low abundance biomarkers. We demonstrated for the first time the detection of sub 13 nm high-moment magnetic nanoparticle and the implementation of a novel magnetoresistive (GMR) biosensor concept with higher sensitivity and 10 times lower external field in real biomarker sensing schemes. A potential lung cancer biomarker, interleukin-6 (IL-6), was successfully detected with extremely low concentration (as few as only 200 pieces of IL-6). Together with other features of GMR sensor systems like low-cost, portability, easy-to-use, our demonstrated device may lead to future family-based personalized medicine for cancer prevention.