Title :
LifeShirt® acquisition system to monitor ECG from ambulatory swine and the implementation of an arrhythmia detection algorithm
Author :
Kyle, Aaron M. ; Rogers, Pamela I. ; Han, Seongwook ; Chen, Peng-Sheng ; March, Keith L.
Author_Institution :
Sch. of Med., Indiana Center for Vascular Biol. & Med. (ICVBM), Indiana Univ., Indianapolis, IN, USA
Abstract :
A wearable cardiopulmonary monitoring system, a LifeShirtreg, was used to acquire continuous electrocardiograms (ECGs) from ambulatory swine. The animals received intracoronary injections of autologous mesenchymal stem cells, and the LifeShirtreg was used for long-duration ECG monitoring in pre-defined periods post cell infusion. The system used here was developed for measurements from non-human primates and canines; however, we demonstrated that it could be used to non-invasively measure ECGs from swine without creating undue stress or restricting movement. A MATLAB-based analysis algorithm was developed to automatically detect premature ventricular contractions (PVCs) that arose 8-10 hours after cell delivery with spontaneous resolution 2-3 days post-infusion. Template based cross-correlation was used to detect the PVCs and identify regions of consecutive ventricular rhythm. The final algorithm was highly specific and sensitive when tested on records from the MIT-BIH arrhythmia database. The algorithm was subsequently used to automatically identify and quantify PVCs from over 200 hours of ECG data obtained from nine ambulatory swine.
Keywords :
cardiovascular system; cellular biophysics; data acquisition; electrocardiography; LifeShirt acquisition system; MATLAB; MIT-BIH arrhythmia database; ambulatory swine; arrhythmia detection algorithm; autologous mesenchymal stem cells; canines; continuous electrocardiogram; intracoronary injections; long-duration ECG monitoring; nonhuman primates; post cell infusion; premature ventricular contractions; wearable cardiopulmonary monitoring system; Algorithms; Animals; Arrhythmias, Cardiac; Electrocardiography; Female; Male; Mesenchymal Stem Cell Transplantation; Swine; Ventricular Premature Complexes;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5332632