Title :
Microfluidic neurotransmiter-based neural interfaces for retinal prosthesis
Author :
Iezzi, Raymond ; Finlayson, Paul ; Xu, Yong ; Katragadda, Rakesh
Author_Institution :
Mayo Clinic, Rochester, MN, USA
Abstract :
Natural inter-neuronal communication is mediated primarily via neurotransmitter-gated ion channels. While most of the methods for neural interfacing have been based upon electrical stimulation, neurotransmitter-based approaches for the spatially and temporally controlled delivery of neurotransmitters are relatively new. Methods of neurotransmitter stimulation retinal prosthesis may provide new ways to control neural excitation. Experimental results for retinal ganglion cell stimulation demonstrate the feasibility of a neurotransmitter-based retinal prosthesis.
Keywords :
biomembrane transport; eye; microfluidics; neurophysiology; prosthetics; microfluidic neurotransmiter-based neural interfaces; natural interneuronal communication; neural excitation; neural interfacing; neurotransmitter stimulation; neurotransmitter-gated ion channels; retinal ganglion cell stimulation; retinal prosthesis; Animals; Electric Stimulation; Evoked Potentials; Glutamic Acid; Male; Neurotransmitter Agents; Prostheses and Implants; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Time Factors;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5332694