• DocumentCode
    2377938
  • Title

    Microfluidic neurotransmiter-based neural interfaces for retinal prosthesis

  • Author

    Iezzi, Raymond ; Finlayson, Paul ; Xu, Yong ; Katragadda, Rakesh

  • Author_Institution
    Mayo Clinic, Rochester, MN, USA
  • fYear
    2009
  • fDate
    3-6 Sept. 2009
  • Firstpage
    4563
  • Lastpage
    4565
  • Abstract
    Natural inter-neuronal communication is mediated primarily via neurotransmitter-gated ion channels. While most of the methods for neural interfacing have been based upon electrical stimulation, neurotransmitter-based approaches for the spatially and temporally controlled delivery of neurotransmitters are relatively new. Methods of neurotransmitter stimulation retinal prosthesis may provide new ways to control neural excitation. Experimental results for retinal ganglion cell stimulation demonstrate the feasibility of a neurotransmitter-based retinal prosthesis.
  • Keywords
    biomembrane transport; eye; microfluidics; neurophysiology; prosthetics; microfluidic neurotransmiter-based neural interfaces; natural interneuronal communication; neural excitation; neural interfacing; neurotransmitter stimulation; neurotransmitter-gated ion channels; retinal ganglion cell stimulation; retinal prosthesis; Animals; Electric Stimulation; Evoked Potentials; Glutamic Acid; Male; Neurotransmitter Agents; Prostheses and Implants; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Time Factors;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
  • Conference_Location
    Minneapolis, MN
  • ISSN
    1557-170X
  • Print_ISBN
    978-1-4244-3296-7
  • Electronic_ISBN
    1557-170X
  • Type

    conf

  • DOI
    10.1109/IEMBS.2009.5332694
  • Filename
    5332694