Title :
Multi-scale modeling of excitation-contraction coupling in the normal and failing heart
Author :
Kerckhoffs, Roy C P ; Campbell, Stuart G. ; Flaim, Sarah N. ; Howard, Elliot J. ; Sierra-Aguado, Jazmin ; Mulligan, L.J. ; McCulloch, Andrew D.
Author_Institution :
Dept of Bioeng., Univ. of California San Diego, La Jolla, CA, USA
Abstract :
Here we describe new computational models of cardiac electromechanics starting from the cellular scale and building to the tissue, organ and system scales. We summarize application to human genetic diseases (LQT1 and LQT3) and to modeling of congestive heart failure.
Keywords :
bioelectric phenomena; biological organs; biological tissues; biomechanics; cardiology; cellular biophysics; diseases; electromechanical effects; genetics; physiological models; cardiac electromechanics; cellular scale; computational model; congestive heart failure modeling; excitation-contraction coupling; heart failure model; human genetic diseases; multiscale modeling; organ scales; tissue scales; Algorithms; Computer Simulation; Electrophysiology; Equipment Design; Heart; Heart Conduction System; Heart Failure; Humans; Long QT Syndrome; Models, Cardiovascular; Models, Genetic; Muscle Cells; Mutation; Myocardial Contraction; Software;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5332708
