Title :
Process Calculi for Systems Biology and applications in severe asthma
Author :
Baroukh, Caroline ; Rowe, Anthony ; Guo, Yike
Author_Institution :
Dept. of Comput., Imperial Coll. London, London, UK
Abstract :
In this paper we summarise our current work on using Process Calculi for the modelling and analysis of biological pathways in context of better understanding respiratory disease. We present and highlight key features of some of the different Process Calculi that have been used for the modelling of biological pathways. Then we make a state-of-art on asthma, severe asthma and the possible cause of corticosteroids resistance. Finally we described a simple model of p38 pathway using Bio-PEPA framework and its transformation so as to include corticosteroids insensitivity in severe asthma.
Keywords :
diseases; medical diagnostic computing; physiological models; pneumodynamics; Bio-PEPA; biological pathways; corticosteroids; p38 pathway; process calculi; respiratory disease; severe asthma; systems biology;
Conference_Titel :
Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on
Conference_Location :
Hong, Kong
Print_ISBN :
978-1-4244-8303-7
Electronic_ISBN :
978-1-4244-8304-4
DOI :
10.1109/BIBMW.2010.5703802
