A new analytic model of urea kinetics oriented to parameter estimation

Author

Grandi, F. ; Chiari, L. ; Cappello, A. ; Avanzolini, G.

Author_Institution

DEIS, Bologna Univ., Italy

fYear

1994

fDate

1994

Firstpage

1164

Abstract

An analytic solution of the variable volume double-pool urea kinetics model and its application to the estimation of urea distribution volume and generation rate during dialysis, are presented. The estimation of these clinically relevant parameters starting from only three blood samples requires the assumption of constant values for the diffusion coefficient and the intra-extracellular volume ratio. Results obtained from computer simulations show that the effect of a ±50% variation of these parameters influences the estimates less than standard measurement errors

Keywords

blood; analytic model; blood samples; clinically relevant parameters; computer simulations; dialysis; diffusion coefficient; generation rate; intra-extracellular volume ratio; parameter estimation; urea distribution volume; urea kinetics; variable volume double-pool urea kinetics model; Character generation; Differential equations; Extracellular; High K dielectric materials; Kinetic theory; Measurement errors; Nonlinear equations; Numerical simulation; Parameter estimation; Phase estimation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Conference_Location

Baltimore, MD

Print_ISBN

0-7803-2050-6

Type

conf

DOI

10.1109/IEMBS.1994.415374

Filename

415374