Title :
A new analytic model of urea kinetics oriented to parameter estimation
Author :
Grandi, F. ; Chiari, L. ; Cappello, A. ; Avanzolini, G.
Author_Institution :
DEIS, Bologna Univ., Italy
Abstract :
An analytic solution of the variable volume double-pool urea kinetics model and its application to the estimation of urea distribution volume and generation rate during dialysis, are presented. The estimation of these clinically relevant parameters starting from only three blood samples requires the assumption of constant values for the diffusion coefficient and the intra-extracellular volume ratio. Results obtained from computer simulations show that the effect of a ±50% variation of these parameters influences the estimates less than standard measurement errors
Keywords :
blood; analytic model; blood samples; clinically relevant parameters; computer simulations; dialysis; diffusion coefficient; generation rate; intra-extracellular volume ratio; parameter estimation; urea distribution volume; urea kinetics; variable volume double-pool urea kinetics model; Character generation; Differential equations; Extracellular; High K dielectric materials; Kinetic theory; Measurement errors; Nonlinear equations; Numerical simulation; Parameter estimation; Phase estimation;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.415374
