Title :
Modeling of glucose transport in skeletal muscle
Author :
Lv, Dayu ; Goodwine, Bill
Author_Institution :
Dept. of Aerosp. & Mech. Eng., Univ. of Notre Dame, Notre Dame, IN, USA
Abstract :
Glucose cannot be properly regulated by insulin in type 2 diabetics. In skeletal muscle, glucose is carried into muscle mainly by glucose transporter type 4 (GLUT4), which is stimulated by insulin and exercise. This paper presents a mechanistic model of glucose transport in skeletal muscle. The model parameters are obtained by a deterministic optimization method called DIRECT.
Keywords :
biochemistry; biotransport; diseases; muscle; sugar; DIRECT; GLUT4; deterministic optimization method; exercise; glucose transporter type 4; insulin; mechanistic model; skeletal muscle; type 2 diabetics; GLUT4; glucose transport; metabolism modeling; skeletal muscle;
Conference_Titel :
Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on
Conference_Location :
Hong, Kong
Print_ISBN :
978-1-4244-8303-7
Electronic_ISBN :
978-1-4244-8304-4
DOI :
10.1109/BIBMW.2010.5703931
