Title :
Genome-wide DNA methylation analysis in tumor and normal tissues from lung squamous cell carcinoma and serous cystadenocarcinoma
Author :
Inaoka, Hidenori ; Noshiro, Makoto ; Fukuoka, Yutaka
Author_Institution :
Sch. of Allied Health Sci., Kitasato Univ., Sagamihara, Japan
Abstract :
Genome-wide DNA methylation was analysed in tumor and normal tissues. HOXA9, HOXD4, TBX4 were found to be hypermethylated in tumor tissues whereas PAX4 was found to be hypermethylated in normal tissues. HOXD4 and TBX4 are suggested to be potent tumor suppressor genes or tumor suppressor associated genes.
Keywords :
DNA; biochemistry; bioinformatics; cancer; cellular biophysics; genetics; genomics; molecular biophysics; tumours; HOXA9; HOXD4; PAX4; TBX4; genome-wide DNA methylation analysis; hypermethylation; lung squamous cell carcinoma; normal tissues; serous cystadenocarcinoma; tumor suppressor associated genes; tumor suppressor genes; DNA methylation; tumor;
Conference_Titel :
Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on
Conference_Location :
Hong, Kong
Print_ISBN :
978-1-4244-8303-7
Electronic_ISBN :
978-1-4244-8304-4
DOI :
10.1109/BIBMW.2010.5703943
