Title :
Modifications to the Wilders-Jongma-van Ginneken model of pacemaker electrical activity
Author :
Dokos, Socrates ; Celler, Branko ; Lovel, Nigel
Author_Institution :
Sch. of Electr. Eng., New South Wales Univ., Kensington, NSW, Australia
Abstract :
The Wilders-Jongsma-van Ginneken single cell model of sinoatrial node electrical activity was found to be unsuitable for simulating autonomic modulation of sinoatrial node rhythm. The equations were modified by reducing the effects of the large sarcoplasmic reticulum calcium store, altering the kinetics of the L-type calcium current, and modifying the activation curve of the hyperpolarizing-activated current if. The resulting model was able to reproduce the chronotropic responses of cardiac period to sympathetic and parasympathetic stimulation
Keywords :
cardiology; Ca; L-type calcium current; Wilders-Jongma-van Ginneken model; activation curve; autonomic modulation; cardiac period; chronotropic responses; hyperpolarizing-activated current; large sarcoplasmic reticulum calcium store; pacemaker electrical activity; parasympathetic stimulation; single cell model; sinoatrial node electrical activity; sinoatrial node rhythm; sympathetic stimulation; Australia; Biological system modeling; Biology; Biomembranes; Calcium; Equations; Kinetic theory; Laboratories; Pacemakers; Rhythm;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.415393
