• DocumentCode
    2382054
  • Title

    A model of vagal control of sinoatrial rhythm

  • Author

    Dokos, Socrates ; Celler, Branko ; Lovell, Nigel

  • Author_Institution
    Sch. of Electr. Eng., New South Wales Univ., Sydney, NSW, Australia
  • fYear
    1994
  • fDate
    1994
  • Firstpage
    1204
  • Abstract
    The single pacemaker cell model of Wilders et. al. (1991) has been modified to simulate the complex negative chronotropic response of cardiac period to brief vagal stimulation. Equations have been added to describe the muscarinic K+ current iK,ACh the [ACh]-modulated pacemaker current if, and acetylcholine uptake and release by vagal stimulation. The resulting model is able to reproduce the experimentally observed triphasic response of cardiac period following brief vagal stimulation
  • Keywords
    biocontrol; [ACh]-modulated pacemaker current; brief vagal stimulation; cardiac period; complex negative chronotropic response; muscarinic K+ current; single pacemaker cell model; sinoatrial rhythm; vagal control model; Australia; Biological system modeling; Biology; Biomembranes; Cells (biology); Equations; Kinetic theory; Laboratories; Pacemakers; Rhythm;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
  • Conference_Location
    Baltimore, MD
  • Print_ISBN
    0-7803-2050-6
  • Type

    conf

  • DOI
    10.1109/IEMBS.1994.415394
  • Filename
    415394
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2382054