DocumentCode :
2382054
Title :
A model of vagal control of sinoatrial rhythm
Author :
Dokos, Socrates ; Celler, Branko ; Lovell, Nigel
Author_Institution :
Sch. of Electr. Eng., New South Wales Univ., Sydney, NSW, Australia
fYear :
1994
fDate :
1994
Firstpage :
1204
Abstract :
The single pacemaker cell model of Wilders et. al. (1991) has been modified to simulate the complex negative chronotropic response of cardiac period to brief vagal stimulation. Equations have been added to describe the muscarinic K+ current iK,ACh the [ACh]-modulated pacemaker current if, and acetylcholine uptake and release by vagal stimulation. The resulting model is able to reproduce the experimentally observed triphasic response of cardiac period following brief vagal stimulation
Keywords :
biocontrol; [ACh]-modulated pacemaker current; brief vagal stimulation; cardiac period; complex negative chronotropic response; muscarinic K+ current; single pacemaker cell model; sinoatrial rhythm; vagal control model; Australia; Biological system modeling; Biology; Biomembranes; Cells (biology); Equations; Kinetic theory; Laboratories; Pacemakers; Rhythm;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
Type :
conf
DOI :
10.1109/IEMBS.1994.415394
Filename :
415394
Link To Document :
https://search.ricest.ac.ir/dl/search/defaultta.aspx?DTC=49&DC=2382054
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