A configurable IC for wireless real-time in vivo monitoring of chemical and electrical neural activity

Author

Roham, Masoud ; Blaha, Charles D. ; Garris, Paul A. ; Lee, Kendall H. ; Mohseni, Pedram

Author_Institution

Electr. Eng. & Comput. Sci. Dept, Case Western Reserve Univ., Cleveland, OH, USA

fYear

2009

fDate

3-6 Sept. 2009

Firstpage

4222

Lastpage

4225

Abstract

A 16-channel chip for wireless in vivo recording of chemical and electrical neural activity is described. The 7.83-mm² IC is fabricated using a 0.5-mum CMOS process and incorporates a 71-muW, 3^rd-order, configurable, DeltaSigma modulator per channel, achieving an input-referred noise of 4.69 muV_rms in 4-kHz BW and 94.1 pA_rms in 5-kHz BW for electrical and fast-scan voltammetric chemical neurosensing, respectively. Brain extracellular levels of dopamine elicited by electrical stimulation of the medial forebrain bundle have been recorded wirelessly on multiple channels using 300-V/s fast-scan cyclic voltammetry in the anesthetized rat.

Keywords

CMOS integrated circuits; biochemistry; bioelectric phenomena; biomedical electronics; biomedical measurement; delta-sigma modulation; medical signal processing; neurophysiology; voltammetry (chemical analysis); CMOS technology; DeltaSigma modulator; anesthetized rat; brain extracellular dopamine level; chemical neural activity; configurable IC; electrical neural activity; electrical stimulation; fast-scan voltammetric chemical neurosensing; input-referred noise; medial forebrain bundle; wireless real-time in vivo monitoring; Animals; Computer Communication Networks; Electronics; Electrophysiology; Equipment Design; Male; Microelectrodes; Models, Neurological; Monitoring, Ambulatory; Nerve Net; Rats; Telemetry; Time Factors; Transducers;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Conference_Location

Minneapolis, MN

ISSN

1557-170X

Print_ISBN

978-1-4244-3296-7

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2009.5333089

Filename

5333089