Title :
Fabrication of nanostructured PLGA scaffolds using anodic aluminum oxide templates
Author :
Hsueh, Cheng-Chih ; Wang, Gou-Jen ; Hsu, Shan-hui ; Hung, Huey-Shan
Author_Institution :
Dept. of Mech. Eng., Nat. Chung-Hsing Univ., Taichung
Abstract :
PLGA (poly(lactic-co-glycolic acid)) is one of the most used biodegradable and biocompatible materials. Nanostructured PLGA even has great application potentials in tissue engineering. In this research, a fabrication technique for nanostructured PLGA membrane was investigated and developed. In this novel fabrication approach, an anodic aluminum oxide (AAO) film was use as the template; the PLGA solution was then cast on it; the vacuum air-extraction process was applied to transfer the nano porous pattern from the AAO membrane to the PLGA membrane and form nanostures on it. The cell culture experiments of the bovine endothelial cells demonstrated that the nanostructured PLGA membrane can double the cell growing rate. Compared to the conventional chemical-etching process, the physical fabrication method proposed in this research not only is simpler but also does not alter the characteristics of the PLGA. The nanostructure of the PLGA membrane can be well controlled by the AAO temperate.
Keywords :
biomembranes; cellular biophysics; nanofabrication; nanostructured materials; polymers; anodic aluminum oxide templates; bovine endothelial cells; cell culture experiments; membrane; nanostructured poly(lactic-co-glycolic acid); vacuum air-extraction process; Aluminum oxide; Biodegradable materials; Biological materials; Biomembranes; Bovine; Chemical processes; Fabrication; Nanostructured materials; Temperature control; Tissue engineering;
Conference_Titel :
Design, Test, Integration and Packaging of MEMS/MOEMS, 2008. MEMS/MOEMS 2008. Symposium on
Conference_Location :
Nice
Print_ISBN :
978-2-35500-006-5
DOI :
10.1109/DTIP.2008.4753004