Title :
Which one is more effective in Parkinson´s disease? stimulating the motor cortex or the basal ganglia?
Author :
Ahvi, A.N. ; Bahrami, F.
Author_Institution :
Sch. of Electr. & Comput. Eng., Univ. of Tehran, Tehran, Iran
Abstract :
In this paper we investigated by a computational model of the basal ganglia-thalamocortical system (BGTCS) differences between the motor cortex stimulation (MCS) and deep brain stimulation (DBS) of the subthalamic nucleus (STN) of the basal ganglia (BG) in Parkinson´s disease (PD). To this end, a mean-field model of the BGTCS is used. This model is able to reproduce both the normal and parkinsonian activities of the BG, thalamus and motor cortex in a unified structure. Using this model, we simulate DBS and MCS, and compared the effect of location of stimulation on mean firing rates of the BGTCS. Our results suggest that DBS of the STN and MCS could restore thalamus relay activity, but DBS effects on PD are stronger than MCS. Consequently, stimulation of cortex seems to mimic the stimulation of STN in a relatively less effective manner. Our results are compatible with the experimental and the clinical outcomes on the effects of DBS and MCS.
Keywords :
bioelectric phenomena; brain models; diseases; neurophysiology; BGTCS mean field model; Parkinson´s disease; Parkinsonian brain activities; basal ganglia stimulation; basal ganglia subthalamic nucleus; basal ganglia-thalamocortical system computational model; deep brain stimulation; mean firing rate; motor cortex stimulation; normal brain activities; stimulation location effects; Diseases; Relays; basal ganglia thalamocortical system; deep brain stimulation; motor cortex stimulation; parkinson´s disease;
Conference_Titel :
Biomedical Engineering (ICBME), 2010 17th Iranian Conference of
Conference_Location :
Isfahan
Print_ISBN :
978-1-4244-7483-7
DOI :
10.1109/ICBME.2010.5704973
