Model based reconstruction for simultaneously imaging cerebral blood flow and De-oxygen hemoglobin distribution

Laser speckle imaging (LSI) and optical intrinsic signal (OIS) imaging are shown to produce high resolution information of cerebral blood flow (CBF) and de-oxygen hemoglobin (dHb) respectively. However, the cortex curvature and non-uniform illumination always result in the inhomogeneous impact and thus distort the CBF and dHb results. In this paper, we propose to extract both CBF and dHb images from raw speckle images. A parametric model for such inhomogeneity is estimated by adaptive window median-mean filtering and curve fitting technique to reconstruct the CBF and dHb image.