DocumentCode :
2395839
Title :
A univariate model of calcium release in the dyadic cleft of cardiac myocytes
Author :
Fan, Junjie ; Yu, Zeyun
Author_Institution :
Dept. of Comput. Sci., Univ. of Wisconsin-Milwaukee, Milwaukee, WI, USA
fYear :
2009
fDate :
3-6 Sept. 2009
Firstpage :
4499
Lastpage :
4503
Abstract :
Local calcium sparks in the dyadic cleft of cardiac myocytes are triggered by calcium influxes via L-type calcium channels (LCCs) located on the transverse tubule (TT) membrane, and subsequently controlled by the regeneration of ryanodine receptors (RyRs) on the sarcoplasmic reticulum (SR). Calcium released from SR channels is known to be responsible for the sparks. Therefore, the activities of RyRs provide straightforward indication to the calcium concentration alteration. A method to study calcium signaling by analyzing RyR-gating statistics is described in the present study. Here we propose a univariate model with a simplified geometry of the dyadic cleft, which specifies the spatial localization of LCCs and RyRs to monitor the activity changes of RyRs. This model is used to explore two crucial aspects of local calcium signaling: the first is to disclose the tight control of calcium influxes via LCCs, and the second is to reveal the interactional impact of the self-regenerative RyRs. Patterns of active RyRs are rendered through numerous computational simulation experiments, manipulating the state initialization and the spatial localization of LCCs and RyRs to observe gating transition of RyRs.
Keywords :
biochemistry; bioelectric phenomena; biomembrane transport; calcium; cellular biophysics; L-type calcium channels; RyR-gating statistics; calcium concentration alteration; calcium release; cardiac myocytes; dyadic cleft; local calcium sparks; ryanodine receptors regeneration; sarcoplasmic reticulum; transverse tubule membrane; Algorithms; Analysis of Variance; Calcium; Calcium Channels, L-Type; Computer Simulation; Models, Cardiovascular; Models, Statistical; Monte Carlo Method; Myocytes, Cardiac; Ryanodine Receptor Calcium Release Channel; Stochastic Processes;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
ISSN :
1557-170X
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2009.5333685
Filename :
5333685
Link To Document :
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