Title :
Modulation of arousal regulation with central thalamic deep brain stimulation
Author :
Shah, Sudhin A. ; Baker, Jonathan L. ; Ryou, Jae-Wook ; Purpura, Keith P. ; Schiff, Nicholas D.
Author_Institution :
Physiol., Biophys. & Syst. Biol. Dept., Weill Cornell Grad. Sch. of Biomed. Sci., New York, NY, USA
Abstract :
To investigate the effects of central thalamic deep brain stimulation (CT/DBS) on behavior and frontal cortical function, we conducted experiments in an awake, behaving macaque monkey performing tasks that required sustained attention and working memory. Results of this preliminary study revealed that CT/DBS can lead to an improvement, a decrement, a mixed or have no effect on behavior.
Keywords :
bioelectric potentials; brain; medical signal processing; neurophysiology; patient treatment; arousal regulation modulation; central thalamic deep brain stimulation; sustained attention; working memory; Adult; Animals; Arousal; Attention; Behavior; Behavior, Animal; Brain; Deep Brain Stimulation; Electrophysiology; Humans; Macaca; Male; Memory, Short-Term; Neural Pathways; Neurons;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5333751
